Пространственные и сетчатые конструкции, Вернадский, Шухов, Ладовский, Крутиков, Мельников, Савельев, Мухин, Шевнин, Shevnin, геномная архитектура

среда, 19 марта 2008 г.

The Origins of Genome Architecture

Michael Lynch
2007
About the Book
With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter.

Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch’s hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.

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About the Author

Michael Lynch is a Distinguished Professor in the Department of Biology at Indiana University. He received his B.S. in Biology from St. Bonaventure University, and his Ph.D. in Ecology from the University of Minnesota. Dr. Lynch is a former President of the Society for the Study of Evolution, current President of the American Genetics Association, council member of the Society for Molecular Biology and Evolution, and fellow of the American Academy of Arts and Sciences. In 1998, he and Bruce Walsh coauthored Genetics and Analysis of Quantitative Traits. His research is focused on the mechanisms of evolution at the molecular, genomic, and phenotypic levels, and makes use of equations and several model systems (Daphnia, Caenorhabditis, Paramecium, and Saccharomyces).

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Reviews and Commentary

“This book is a must-read for every genome researcher … It is the best, most up-to-date and thorough summary of genome evolution published. … Almost every page introduces interesting, unanswered problems, making it a gold mine for graduate students in search of a thesis topic.”
—Axel Meyer, Nature

“If you want a good summary of what genomics has revealed about genome architecture over the last two decades, merged with a nontechnical exposition of the relevant principles of population genetics, this is the book to get.”
—Daniel Hartl, Nature Genetics

“Lynch presents a synthesis of molecular genetics and evolutionary biology with a goal of driving new interdisciplinary research and understanding. He succeeds admirably. This extremely interesting book presents genomic evolution in a comprehensive manner and with different perspectives. … What makes this volume so useful is that each chapter presents not only what and how, but also why (and why it matters). This book will appeal to everyone interested in genetics, molecular biology, and evolution. Highly recommended.”
—D. Carroll, Choice

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